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KMID : 0380620130450020206
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Korean Journal of Food Science and Technology
2013 Volume.45 No. 2 p.206 ~ p.212
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Antioxidant Activity and Inhibitory Effect of Taraxacum officinale Extracts on Nitric Oxide Production
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Min Kyung-Chun
Jhoo Jin-Woo
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Abstract
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In the current study, antioxidant properties of extracts from different parts of Taraxacum officinale were determined by measuring the radical scavenging activity of 1,1-diphenyl-2-picryl hydrazyl(DPPH) and 2,2'-Azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS). The antioxidant activity of aerial and root parts of this plant was measured in extracts obtained from various solvents, e.g., water, 50, 70, 100% ethanol, and hot-water. The hot-water extracts had the highest radical scavenging activities. A further study was conducted to determine the total antioxidant activity of hotwater extract fractions obtained from different solvents, e.g., chloroform, ethyl acetate, n-butanol, and water. The ethyl acetate fraction of this extract displayed the strongest DPPH and ABTS radical scavenging activity and the highest total phenolic contents. The inhibitory effect of individual solvent fractions on the production of nitric oxide in LPS-stimulated RAW 264.7 cells was measured. The results indicated that the ethyl acetate fraction of aerial and roots part extracts significantly reduced nitric oxide productions.
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KEYWORD
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antioxidant activity, nitric oxide, radical scavenging activity, RAW 264.7 murine macrophage, Taraxacum officinale
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